Journal of Investigative Dermatology

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Dynamical network biomarkers: Theory and applications

Gene

Extending support for mouse data in the Molecular Signatures Database (MSigDB)

Nat Methods

Detecting early-warning signals for sudden deterioration of complex diseases by dynamical network biomarkers

Sci Rep

Slowing down as an early warning signal for abrupt climate change

Proc Natl Acad Sci U S A

The prevalence of positive reactions in the atopy patch test with aeroallergens and food allergens in subjects with atopic eczema: a European multicenter study

Allergy

Endoplasmic reticulum stress and the inflammatory response in allergic contact dermatitis

Eur J Immunol

IRE1 and PERK signaling regulates inflammatory responses in a murine model of contact hypersensitivity

Should Emollients Be Recommended for the Prevention of Atopic Dermatitis?-New Evidence and Current State of Knowledge

J Clin Med

simplifyEnrichment: A Bioconductor Package for Clustering and Visualizing Functional Enrichment Results

Genomics Proteomics Bioinformatics

Dynamic network biomarker identifies cdkn1a-mediated bone mineralization in the triggering phase of osteoporosis

Exp Mol Med

GSVA: gene set variation analysis for microarray and RNA-seq data

BMC Bioinformatics

Tape strips detect distinct immune and barrier profiles in atopic dermatitis and psoriasis

J Allergy Clin Immunol

Effect of tacrolimus hydrate (FK506) ointment on spontaneous dermatitis in NC/Nga mice

Jpn J Pharmacol

Application of moisturizer to neonates prevents development of atopic dermatitis

Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids

Commun Biol

Endoplasmic Reticulum Stress and Allergic Diseases

Curr Allergy Asthma Rep

Oxidative Stress in Atopic Dermatitis

Oxid Med Cell Longev

Dynamic network biomarker to determine the critical point of breast cancer stage progression

Breast Cancer

Animal models of atopic dermatitis

J Invest Dermatol

New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity

J Dermatol Sci

Research Techniques Made Simple: Mouse Models of Atopic Dermatitis

Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis

Immunity

Identifying pre-disease signals before metabolic syndrome in mice by dynamical network biomarkers

Identifying critical transitions and their leading biomolecular networks in complex diseases

Hunt for the tipping point during endocrine resistance process in breast cancer by dynamic network biomarkers

J Mol Cell Biol

Detection for disease tipping points by landscape dynamic network biomarkers

Natl Sci Rev

Detecting early-warning signals of type 1 diabetes and its leading biomolecular networks by dynamical network biomarkers

BMC Med Genomics

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Genome Biol

Early warnings for multi-stage transitions in dynamics on networks

J R Soc Interface

Anticipating regime shifts by mixing early warning signals from different nodes

Nat Commun

Atopic dermatitis: global epidemiology and risk factors

Ann Nutr Metab

Two Novel Methods for Extracting Synchronously Fluctuated Genes

IPSJ Trans. Bioinform

Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes

Mechanisms of IFN-gamma-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis

Biomarkers in atopic dermatitis-a review on behalf of the International Eczema Council

Skin Mast Cell-Driven Ceramides Drive Early Apoptosis in Pre-Symptomatic Eczema in Mice

Int J Mol Sci

ER stress-induced cell death mechanisms

Biochim Biophys Acta

Early-warning signals for critical transitions

Nature

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

NC/Nga mice: a mouse model for atopic dermatitis

Int Arch Allergy Immunol

Effects of anti-nerve growth factor antibody on symptoms in the NC/Nga mouse, an atopic dermatitis model

J Pharmacol Sci

Role of apoptosis in atopic dermatitis

Recovery rates reflect distance to a tipping point in a living system

Eczema in early childhood is strongly associated with the development of asthma and rhinitis in a prospective cohort

BMC Dermatol

clusterProfiler 4.0: A universal enrichment tool for interpreting omics data

Innovation (Camb)

Enhanced early skin treatment for atopic dermatitis in infants reduces food allergy

Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma

Potential biomarkers of atopic dermatitis

Front Med (Lausanne)

Landscape dynamic network biomarker analysis reveals the tipping point of transcriptome reprogramming to prevent skin photodamage

From endoplasmic-reticulum stress to the inflammatory response

Atopic dermatitis (AD) is a common skin disease worldwide characterized by itchy eczema that undergoes cycles of exacerbation and remission. While several biomarkers reflect AD severity, reliable markers for predicting disease onset and recurrence remain unclear. The dynamical network biomarker (DNB) theory detects pre-disease states, or pre-symptomatic states by analyzing characteristic network fluctuations just before phase transitions from healthy states to disease states. To investigate the applicability of DNB theory to AD, we conducted blood transcriptome analysis in NC/Nga mice before and after the onset of AD-like dermatitis. We identified 356 DNB genes whose temporal fluctuations enabled the detection of the pre-disease state preceding AD-like dermatitis onset. These genes were significantly enriched in pathways related to endoplasmic reticulum stress and apoptosis; fluctuations in these pathways may be associated with the onset of AD. Our study indicates that the DNB theory may be applicable to AD and that identifying a pre-disease state may enable early intervention and disease prevention. Collectively, this approach could provide valuable insights into maintaining long-term remission and improving AD management strategies.

Identification of Pre-Disease State in NC/Nga Mice with Atopic Dermatitis-Like Symptoms Using Dynamical Network Biomarkers.

Identification of Pre-Disease State in NC/Nga Mice with Atopic Dermatitis-Like Symptoms Using Dynamical Network Biomarkers

Identification of Pre-Disease State in NC/Nga Mice with Atopic Dermatitis-Like Symptoms Using Dynamical Network Biomarkers

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