Journal of the American Academy of Dermatology

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UVA radiation is highly mutagenic in cells that are unable to repair 7,8-dihydro-8-oxoguanine in Saccharomyces cerevisiae

Proc Natl Acad Sci USA

Ultraviolet light induced generation of reactive oxygen species

Adv Exp Med Biol

Photoaging: a review of current literature

Curr Derm Rep

UVA Radiation, DNA damage, and melanoma

ACS Omega

Mitochondrial DNA deletions in human skin reflect photo- rather than chronologic aging

J Invest Dermatol

The use of a 3895 bp mitochondrial DNA deletion as a marker for sunlight exposure in human skin

The incidence of both tandem duplications and the common deletion in mtDNA from three distinct categories of sun-exposed human skin and in prolonged culture of fibroblasts

Real-time polymerase chain reaction analysis of a 3895-bp mitochondrial DNA deletion in epithelial swabs and its use as a quantitative marker for sunlight exposure in human skin

Br J Dermatol

Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion

J Biol Chem

Sunscreens and photoaging: a review of current literature

Am J Clin Dermatol

Polypodium leucotomos extract: antioxidant activity and disposition

Toxicol In Vitro

Impact of visible light on skin health: The role of antioxidants and free radical quenchers in skin protection

J Am Acad Dermatol

Decrease of ultraviolet A light-induced “common deletion” in healthy volunteers after oral Polypodium leucotomos extract supplement in a randomized clinical trial

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress

Free Radic Biol Med

From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology

Physiol Rev

Cannabidiol regulates the expression of keratinocyte proteins involved in the inflammation process through transcriptional regulation

Cells

Antioxidant function of phytocannabinoids: Molecular basis of their stability and cytoprotective properties under UV-irradiation

Nanomedicines to treat skin pathologies with natural molecules

Curr Pharm Des

Sustained release nitric oxide releasing nanoparticles: characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites

Nitric Oxide

Nitric oxide-releasing microparticles as a potent antimicrobial therapeutic against chronic rhinosinusitis bacterial isolates

Int Forum Allergy Rhinol

8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis

Cancer Res

Chronically ultraviolet-exposed human skin shows a higher mutation frequency of mitochondrial DNA as compared to unexposed skin and the hematopoietic system

Photochem Photobiol

Triplex real-time PCR—an improved method to detect a wide spectrum of mitochondrial DNA deletions in single cells

Sci Rep

Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR

Nucleic Acids Res

Antioxidative and anti-inflammatory properties of cannabidiol

Antioxidants (Basel)

Heme oxygenase-1 and carbon monoxide: emerging therapeutic targets in inflammation and allergy

Recent Pat Inflamm Allergy Drug Discov

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

Cell Mol Life Sci

Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors

Br J Pharmacol

Therapeutic potential of cannabidiol (CBD) for skin health and disorders

Clin Cosmet Investig Dermatol

The differences in the proteome profile of cannabidiol-treated skin fibroblasts following UVA or UVB irradiation in 2D and 3D cell cultures

Changes in lipid profile of keratinocytes from rat skin exposed to chronic UVA or UVB radiation and topical application of cannabidiol

Human 8-oxoguanine-DNA glycosylase-1 is downregulated in human basal cell carcinoma

Mol Genet Metab

Mitochondrial DNA damage as a biomarker for ultraviolet radiation exposure and oxidative stress

Mitochondrial common deletion, a potential biomarker for cancer occurrence, is selected against in cancer background: a meta-analysis of 38 studies

PLoS One

Dermatologic manifestations of mitochondrial dysfunction: a review of the literature

Int J Mol Sci

Mitochondrial DNA deletion percentage in sun exposed and non sun exposed skin

J Photochem Photobiol B

Real-time PCR analysis of a 3895 bp mitochondrial DNA deletion in nonmelanoma skin cancer and its use as a quantitative marker for sunlight exposure in human skin

Br J Cancer

Mitochondrial DNA copy number—but not a mitochondrial tandem CC to TT transition—is increased in sun-exposed skin

Exp Dermatol

Assessment of UV protection for children’s summer clothing

Cureus

Photoprotection for people with skin of colour: needs and strategies

Contact allergy to cannabis and related essential oils

Dermatitis

Pharmacology of medical cannabis

UV-A radiation contributes to photoaging/photocarcinogenesis by generating inflammation and oxidative damage. Current photoprotective strategies are limited by the availability/utilization of UV-A filters, highlighting an unmet need. Cannabidiol (CBD), having anti-inflammatory/antioxidant properties via regulation of nuclear erythroid 2-related factor, heme oxygenase 1, and peroxisome proliferator-activated receptor gamma, could potentially mitigate damage from UV-A exposure.
This is a prospective, single-center, pilot clinical trial (NCT05279495). Nineteen participants applied nano-CBD (nCBD) or vehicle (VC) cream to randomized, blinded buttock sites twice daily for 14 days; then, the treated sites were irradiated with ≤3× UV-A minimal erythema dose. After 24 hours, punch biopsies were obtained for histology, immunohistochemistry, and real-time polymerase chain reaction.
At 24 hours, 21% of participants had less observed erythema on CBD-treated skin than on VC skin. Histologically, nCBD-treated skin had reduced UV-A-induced epidermal hyperplasia than VC (P = .01). Immunohistochemistry detected reduced cytoplasmic/nuclear 8-oxoguanine glycosylase 1 staining in nCBD-treated skin compared with VC (P < .01). Quantitative mtDNA polymerase chain reaction demonstrated that UV-A-induced deletion of ND4 (proxy:4977 bp deletion; P = .003) and ND1 (proxy:3895 bp deletion; P = .002) was significantly reduced by in vivo nCBD treatment compared with VC.
Small sample size is this study's limitation.
Topically applied nCBD cream reduced UV-A-induced formation of a frequent mutagenic nuclear DNA base lesion and protected against mtDNA mutations associated with UV-A-induced skin aging. To our knowledge, this trial is the first to identify UV-protective capacity of CBD-containing topicals in humans.

Topical nanoencapsulated cannabidiol cream as an innovative strategy combating UV-A-induced nuclear and mitochondrial DNA injury: A pilot randomized clinical study.

Topical nanoencapsulated cannabidiol cream as an innovative strategy combating UV-A–induced nuclear and mitochondrial DNA injury: A pilot randomized clinical study

Advances in Skin &amp; Wound Care

<jats:title>ABSTRACT</jats:title>
          <jats:sec>
            <jats:title>OBJECTIVE</jats:title>
            <jats:p>To explore the effect of topical cannabidiol (CBD) in treating digital ulcers in patients with systemic sclerosis (SSc).</jats:p>
          </jats:sec>
          <jats:sec>
            <jats:title>METHODS</jats:title>
            <jats:p>In total, 45 patients with SSc who had digital ulcers were consecutively enrolled between January 2019 and December 2019. Of the participants, 25 were treated with CBD during surgical debridement and 20 were treated with standard local therapy. A numeric rating scale for pain and Health Assessment Questionnaire Disability Index were administered at the baseline and at the end of treatment.</jats:p>
          </jats:sec>
          <jats:sec>
            <jats:title>RESULTS</jats:title>
            <jats:p>Local treatment with CBD was significantly associated with lower pain scores, higher health assessment scores, and an increase in participants’ total hours of sleep. Patients in the control group more frequently required additional analgesic therapy.</jats:p>
          </jats:sec>
          <jats:sec>
            <jats:title>CONCLUSIONS</jats:title>
            <jats:p>Topical CBD may be a valuable tool to treat pain related to digital ulcers in patients with SSc.</jats:p>
          </jats:sec>

Scleroderma skin ulcers definition, classification and treatment strategies our experience and review of the literature

Autoimmunity Rev

“Less pain with more gain”—Managing wound-related pain with cannabis-based medicines

Wound Repair Regen

Procedural pain management in the treatment of scleroderma digital ulcers

Clin Exp Rheumatol

Review of local wound management for scleroderma-associated digital ulcers

J Scleroderma Relat Disord

Relationship between opioid treatment and rate of healing in chronic wounds

Medical cannabis in the palliation of malignant wounds—a case report

J Pain Symptom Manage

Classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative

Arthritis Rheum

The IASP classification of chronic pain for ICD-11: functioning properties of chronic pain

Pain

Measures of systemic sclerosis (scleroderma): Health Assessment Questionnaire (HAQ) and Scleroderma HAQ (SHAQ), physician- and patient-rated global assessments, Symptom Burden Index (SBI), University of California, Los Angeles, Scleroderma Clinical Trials Consortium Gastrointestinal Scale (UCLA SCTC GIT) 2.0, Baseline Dyspnea Index (BDI) and Transition Dyspnea Index (TDI) (Mahler’s index), Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR), and Raynaud’s Condition Score (RCS)

Arthritis Care Res

Topical opioids for painful ulcers in systemic sclerosis

Ann Rheum Dis

Oxycodone in the long-term treatment of chronic pain related to scleroderma skin ulcers

Pain Med

Effectiveness and safety of oxycodone/naloxone in the management of chronic pain in patients with systemic sclerosis with recurrent digital ulcers: two case reports

Clin Interv Aging

Topical application of morphine for wound healing and analgesia in patients with oral lichen planus: a randomized, double-blind, placebo-controlled study

Clin Oral Investig

Cannabinoid signaling in the skin: therapeutic potential of the “c(ut)annabinoid” system

Molecules

The epigenetic regulation of wound healing

Adv Wound Care

Cannabidiol restores differentiation capacity of LPS exposed adipose tissue mesenchymal stromal cells

Exp Cell Res

A new treatment paradigm for sickle cell disease leg ulcers: topical cannabis-based medicines

Self-initiated use of topical cannabidiol oil for epidermolysis bullosa

Pediatr Dermatol

Topical medical cannabis: a new treatment for wound pain—three cases of pyoderma gangrenosum

Promoting wound healing of uremic calciphylaxis leg ulcers using topical cannabis-based medicines

Dermatol Ther

Topical cannabis-based medicines—a novel paradigm and treatment for non-uremic calciphylaxis leg ulcers: an open label trial

Int Wound J

Topical cannabis-based medicines—a novel adjuvant treatment for venous leg ulcers: an open-label trial

To explore the effect of topical cannabidiol (CBD) in treating digital ulcers in patients with systemic sclerosis (SSc).
In total, 45 patients with SSc who had digital ulcers were consecutively enrolled between January 2019 and December 2019. Of the participants, 25 were treated with CBD during surgical debridement and 20 were treated with standard local therapy. A numeric rating scale for pain and Health Assessment Questionnaire Disability Index were administered at the baseline and at the end of treatment.
Local treatment with CBD was significantly associated with lower pain scores, higher health assessment scores, and an increase in participants' total hours of sleep. Patients in the control group more frequently required additional analgesic therapy.
Topical CBD may be a valuable tool to treat pain related to digital ulcers in patients with SSc.

Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review.

Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review

Papers