Journal of Investigative Dermatology

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University of Padua

Microvascular function predicts cardiovascular events in primary prevention: long-term results from the Firefighters and Their Endothelium (FATE) study

Circulation

Microvascular endothelial dysfunction in rheumatoid arthritis

Nat Rev Rheumatol

Peripheral flow response to transient arterial forearm occlusion does not reflect myocardial perfusion reserve

Coronary microvascular dysfunction

N Engl J Med

Impaired coronary microvascular function and increased intima-media thickness in rheumatoid arthritis

Atherosclerosis

Impact of antipsoriatic therapy on endothelial function

Br J Dermatol

Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force

J Am Coll Cardiol

Prognostic meaning of coronary microvascular disease in type 2 diabetes mellitus: A transthoracic Doppler echocardiographic study

J Am Soc Echocardiogr

Coronary flow reserve in systemic rheumatic diseases: a systematic review and meta-analysis

Rheumatol Int

Coronary microvascular dysfunction in asymptomatic patients affected by systemic sclerosis – limited vs. diffuse form

Circulation Journal

Coronary microvascular dysfunction in chronic inflammatory rheumatoid diseases

Eur Heart J

The assessment of endothelial function: from research into clinical practice

Cardiovascular risk in patients with psoriasis: JACC review topic of the week

Risk of myocardial infarction in patients with psoriasis

JAMA

Endothelial cell dysfunction and the pathobiology of atherosclerosis

Circ Res

Arterioscler Thromb Vasc Biol

Impaired coronary microvascular function and its association with disease duration and inflammation in patients with psoriasis

Echocardiography

Integrated noninvasive physiological assessment of coronary circulatory function and impact on cardiovascular mortality in patients with stable coronary artery disease

Endothelial dysfunction over the course of coronary artery disease

Relation of brachial and digital measures of vascular function in the community: the Framingham heart study

Hypertension

Skin microvascular endothelial function as a biomarker in cardiovascular diseases?

Pharmacol Rep

Similarities in coronary function and myocardial deformation between psoriasis and coronary artery disease: the role of oxidative stress and inflammation

Can J Cardiol

Lowering interleukin-12 activity improves myocardial and vascular function compared with tumor necrosis factor-a antagonism or cyclosporine in psoriasis

Circ Cardiovasc Imaging

The pathogenic role of coronary microvascular dysfunction in the setting of other cardiac or systemic conditions

Cardiovasc Res

The many faces of myocardial ischaemia and angina

Effects of interleukin 17A inhibition on myocardial deformation and vascular function in psoriasis

Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database

Application of machine learning to determine top predictors of noncalcified coronary burden in psoriasis: an observational cohort study

J Am Acad Dermatol

Impaired coronary flow reserve as a marker of microvascular dysfunction to predict long-term cardiovascular outcomes, acute coronary syndrome and the development of heart failure

Circ J

Assessment of endothelial function during the loading phase of infliximab in psoriasis: a potential predictor of its drug survival

Int J Dermatol

Interleukin-17 causes Rho-kinase-mediated endothelial dysfunction and hypertension

Subclinical atherosclerosis evolution during 5 years of anti-TNF-alpha treatment in psoriatic arthritis patients

Clin Exp Rheumatol

Impaired coronary flow reserve in young patients affected by severe psoriasis

Long-term prognostic value of coronary flow reserve in psoriasis patients

Treatment with tumor necrosis factor inhibitors restores coronary microvascular function in young patients with severe psoriasis

Chronic inflammation and coronary microvascular dysfunction in patients without risk factors for coronary artery disease

Identifying myocardial ischemia due to coronary microvascular dysfunction in the emergency department: introducing a new paradigm in acute chest pain evaluation

Clin Ther

Coronary flow velocity reserve predicts adverse prognosis in women with angina and no obstructive coronary artery disease: results from the iPOWER study

T cell-derived IL-17A induces vascular dysfunction via perivascular fibrosis formation and dysregulation of NO/cGMP Signaling ⋅

Oxid Med Cell Longev

Prevalence and severity of coronary artery disease linked to prognosis in psoriasis and psoriatic arthritis patients: a multi-centre cohort study

J Intern Med

Prognostic impact of coronary microcirculation abnormalities in systemic sclerosis: a prospective study to evaluate the role of non-invasive tests

Arthritis Res Ther

J Clin Med

IL-17A in psoriasis and beyond: cardiovascular and metabolic implications

Front Immunol

Coronary microvascular dysfunction in patients with psoriasis

J Nucl Cardiol

Association among noncalcified coronary burden, fractional flow reserve, and myocardial injury in psoriasis

J Am Heart Assoc

Impaired coronary flow reserve as a marker of microvascular dysfunction to predict long-term cardiovascular outcomes, acute coronary syndrome and the development of heart failure

Severe psoriasis is associated with an increased cardiovascular risk, which may be independent of the traditional risk factors. Coronary microvascular dysfunction (CMD) has been shown to predict a poor cardiovascular prognosis in the general population and in patients with psoriasis. In this study, we assessed the prevalence and predictors of CMD in a large cohort of patients with psoriasis without clinical cardiovascular disease. A total of 503 patients with psoriasis were enrolled and underwent transthoracic Doppler echocardiography to evaluate coronary microcirculation. Of these, 55 patients were excluded from the analyses because of missing data. Of the 448 patients in this study, 31.5% showed CMD. Higher PASI, longer disease duration, the presence of psoriatic arthritis, and hypertension were independently associated with CMD. An increase of 1 point of PASI and 1 year of psoriasis duration were associated with a 5.8% and 4.6% increased risk of CMD, respectively. In our study, CMD was associated with the severity and duration of psoriasis. This supports the role of systemic inflammation in CMD and suggests that the coronary microcirculation may represent an extracutaneous site involved in the immune-mediated injury of psoriasis. We should diagnose and actively search for CMD in patients with severe psoriasis.

Coronary Microvascular Dysfunction in Asymptomatic Patients with Severe Psoriasis.

Coronary Microvascular Dysfunction in Asymptomatic Patients with Severe Psoriasis

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