Psoriasis: Research & Clinical Takeaways

Expect similar overall methotrexate persistence whether started orally or subcutaneously. If ineffectiveness is the main concern, subcutaneous starts...

For adults with mild to moderate psoriasis on stable topical therapy, a 16-week, dietitian-guided Mediterranean diet produced clinically meaningful...

Expect accelerated epigenetic aging in psoriatic arthritis, while psoriasis alone may not; signals are also seen in pediatric atopic dermatitis and...

In psoriasis without musculoskeletal symptoms, subclinical synovitis is more prevalent than in healthy controls; MRI may detect it more often than...

Dupilumab was associated with a higher relative risk of new-onset psoriasis vs other systemic agents in adults with AD, but the absolute excess risk...

Even when skin disease is controlled on biologics (PASI ≤ 2), about one-third of psoriasis patients show systemic inflammation (hs-CRP ≥ 2 mg/L);...

Once-daily roflumilast foam 0.3% outperformed vehicle for scalp and limited body psoriasis over 8 weeks and reduced itch early, with low adverse...

Patients with CLE appear to have increased ASCVD risk; consider cardiovascular risk screening similar to other higher-risk groups.

A cross-sectional study in France examined the association between self-reported levels of ultraprocessed food consumption and cases of psoriasis.

Expect a higher rate of incident psoriasis with immune checkpoint inhibitors than with chemotherapy or targeted therapies; monitor and counsel...

Home narrowband UV-B was as effective as office-based therapy at 12 weeks, including across all skin phototypes, with higher adherence but more...

In children, higher BMI and weight gain are associated with greater AD risk, while weight loss from overweight to normal weight is associated with...

Low adolescent stress resilience is associated with higher long‑term risk of psoriasis and psoriatic arthritis in men; incorporate psychological...

Do not rely solely on physician-rated severity or visibility to gauge impact. Routinely identify stigmatization and bullying and track change with...

For dermatology patients, short-term systemic JAK/TYK2 inhibitor use did not increase MACE or VTE versus placebo over a median 16 weeks. This...

Fewer than 60% of patients starting systemic immunomodulators received recommended baseline tests. Clinicians should verify TB and hepatitis...

Paradoxical eczema was rare in biologic-treated psoriasis, with the lowest observed risk on IL‑23 inhibitors. Screen for personal history of atopic...

In dermatology RCTs, JAK inhibitors did not increase short-term risk of MACE, death, or VTE vs controls. Use routine cardiovascular/VTE risk...

Roughly one-third of asymptomatic psoriasis patients had CMD on transthoracic Doppler; higher PASI, longer disease duration, psoriatic arthritis, and...

In psoriasis care, higher SDM is linked with greater patient satisfaction; clinicians should implement efficient SDM frameworks to strengthen...

A cross-sectional analysis in the All of Us Research Program examined the association between psoriasis and celiac disease.

Genetically proxied PCSK9 inhibition was linked to lower psoriasis risk: OR 0.69 per SD reduction in LDL (95% CI 0.55-0.88; P=.003) with replication...

No change in clinical practice. These preclinical data support continued clinical testing of oral orismilast as a selective PDE4 inhibitor with broad...

Expect prices of most psoriasis biologics to outpace medical inflation; discuss affordability and coverage with patients and account for budget...